COMPOSITION:
Each 5ml suspension contains 100mg Mebendazole.
MECHANISM OF ACTION:
Vermoxine is a broad-spectrum anthelmintic، which is very effective and well tolerated. Vermoxine affects by irreversible inhibition of glucose absorption، which leads to reduce the storage of ATP and glucogen. Thus causes the death of worms.
INDICATIONS:
Vermoxine is indicated for treatment of: Intestinal nematode infections، ascariasis، enterobiasis، necatoriasis، trichuriasis، cestodes and it is useful in mixed infections. Vermoxine is effective against ova and larvae and is also used at high dosages for treatment of hydatid disease.
DOSAGE AND ADMINISTRATION:
There is no need during the treatment for dietary changes or use of laxatives، except in case of constipation. Dosage for adults and children (over 2 years) is as follows:
For treatment of enterobiasis: 100mg as a single dosage، repeated If necessary after 2 - 3 weeks.
For treatment of ascariasis and trichuriasis: 100mg twice daily for three days.
For treatment of cestodes: 200mg twice daily for three days.
It is advised to repeat treatment after two weeks.
CONTRAINDICATIONS:
hypersensitivity to mebendazole.
SIDE EFFECTS:
Because of poor absorption of Vermoxine from gastrointestinal، side effects are minor. They are such as transient abdominal pain and diarrhea. In very rare cases، the high dosage for treatment of hydatid can produce allergy، liver function disturbances or leucopenia and alopecia.
USE IN PREGNANCY AND LACTATION:
It should not be used in pregnancy and lactation.
ABSORPTION AND ELIMINATION:
Vermoxine is absorbed in a very small quantity by gastrointestinal tract and is metabolized by the liver and excreted by the bile in a metabolized or unmetabolized form. Only 2% of the dosage are excreted by urine. The rest is excreted by feces. Vermoxine highly binds with plasma proteins.
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